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A positive carcinogenicresponse can then be thought of in two ways: as increasednumbers of tumors or subjects with tumors or as a decreasein the time to appearance of tumors.

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Initially pain was mild, butgradually it has become severe and incapacitating. At present, personal oral hygieneis important to remove local etiologic factors, but we have very little influence onthe systemic response.

It was also mentioned that APC respond to bacteria and fungus by the use of patternrecognition receptors (PRR) such as Toll-like receptors (TLR) and the response of APC tothese PRR is to secrete proinflammatory lymphokines (Hernandez-Santos 2012) such as theones mentioned above that posses CRE.

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